Prof. Yigong Shi's laboratory combines structural biology, biochemical and biophysical approaches to elucidate the molecular and chemical basis of fundamental cellular events, with a particular interest in spliceosome-catalyzed pre-mRNA splicing, the mechanism of regulated intramembrane proteolysis, and the initiation of apoptosis.

pre-mRNA splicing

The structure of the intact spliceosome from S. pombe at 3.6 angstrom provides insights into the molecular mechanism of pre-mRNA splicing. Read More

Apoptosis

The structure of the mammalian Apaf-1 apoptosome. Read More